Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors

Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors

Blog Article

Designed ankyrin repeat proteins (DARPins) are engineered proteins comprising consensus designed ankyrin repeats as scaffold.Tightly packed repeats form a continuous hydrophobic core Lowball Tumbler and a large groove-like solvent-accessible surface that creates a binding surface.DARPin domains recognizing a target of interest with high specificity and affinity can be generated using a synthetic combinatorial library and in vitro selection methods.They Urinals can be linked together in a single molecule to build multispecific and multifunctional proteins without affecting expression or function.

The modular architecture of DARPins offers unprecedented possibilities of design and opens avenues for innovative antiviral strategies.